منابع مشابه
Pathophysiology of cancer cachexia.
Cancer cachexia is a frequent complication observed in patients with malignant tumors. Although several decades have passed since the first focus on the metabolic dysfunction's associated with cancer, few effective therapeutic interventions have been successfully introduced into the medical armamentarium. The present study thoroughly reviews the basic pathophysiology of cancer cachexia and the ...
متن کاملPathophysiology of anorexia in the cancer cachexia syndrome
Anorexia is commonly present in persons with cancer and a major component of cancer cachexia. There are multiple causes of anorexia in cancer. Peripherally, these can be due to (i) substances released from or by the tumour, e.g. pro-inflammatory cytokines, lactate, and parathormone-related peptide; (ii) tumours causing dysphagia or altering gut function; (iii) tumours altering nutrients, e.g. z...
متن کاملCachexia: pathophysiology and clinical relevance.
Cachexia causes weight loss and increased mortality. It affects more than 5 million persons in the United States. Other causes of weight loss include anorexia, sarcopenia, and dehydration. The pathophysiology of cachexia is reviewed in this article. The major cause appears to be cytokine excess. Other potential mediators include testosterone and insulin-like growth factor I deficiency, excess m...
متن کاملCardiac Cachexia: Pathophysiology and Clinical Implications
Cardiac cachexia (i.e. body wasting) has long been recognised as a serious complication of chronic heart failure (CHF) which affects many body systems and remains an important and increasing public health problem. The occurrence of wasting in CHF has been known for many centuries but little investigated. Independently of functional disease severity, age, and measures of exercise capacity and ca...
متن کاملCancer cachexia update in head and neck cancer: Pathophysiology and treatment.
The pathophysiology of cancer cachexia remains complex. A comprehensive literature search was performed up to April 2013 using PubMed, the Cochrane Library, Cumulative Index to Nursing and Allied Health Literature, and the Google search engine. In this review, we focus on the different mediators of impaired anabolism and upregulated catabolism that alter the skeletal muscle homeostasis resultin...
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ژورنال
عنوان ژورنال: Revista do Hospital das Clínicas
سال: 2000
ISSN: 0041-8781
DOI: 10.1590/s0041-87812000000500005